Pibby

Pibby is an action-horror metafictional tv series created by Dodge Greenley. It's about Pibby who stars in her own educational cartoon whose world gets invaded by a glitchy, eldritch blob, consuming & absorbing all of her friends. Soon, she finds herself traveling to other worlds & discovering that they are also under threat of being assimilated. While her newfound allies doubt that they'll be able to deal with such an apocalyptic problem, she holds out hope that there's a way of beating it, but before then, she'll need to learn a lot more than she bargained for. (Note: This is just an idea for fun.)

Characters

 * Pibby (Nikki Castillo): A cute little girl who stars as the title character of an education show aimed at preschoolers called Learning With Pibby & when the Glitch takes her friends & destroys her world, embarks on a journey across the cartoon multiverse, learning how to survive & eventually, fight back.
 * Alloy Boy (Marcus Toji): The costumed sidekick from a fictional superhero cartoon & after his partner is taken by the Glitch, he's forced to step up as a full-fledged hero alongside Pibby.
 * Melira (Alex Newell): A wealthy feline villainess, who in her own cartoon, menaces a group of innocent young dogs, but, as the corruption spreads, finds herself having to work with & care for Pibby.
 * Bun Bun (Jack Stanton): Pibby's best friend, who ends up getting taken by the Glitch.
 * The Glitch: The glitchy blob-like horror consuming the multiverse & corrupting everything in it.

Demon Slayer

 * Tanjiro Kamado (Zach Aguilar): The main protagonist of Demon Slayer: Kimetsu no Yaiba who was assimilated by the Glitch to save Nezuko & was given tendrils on his back to reference when he was turned into a demon.
 * Nezuko Kamado (Abby Trott): Tanjiro's little sister from Demon Slayer: Kimetsu no Yaiba who became a demon & as a result, can no longer speak & has almost no memories of her life as a human, but survived the Glitch, thanks to Tanjiro's sacrifice & joins Pibby's team with Melira carrying her in Tanjiro's box.
 * Inosuke Hashibira (Bryce Papenbrook): An ally of Tanjiro & Nezuko who Tanjiro was fighting before he got assimilated.

JoJo's Bizarre Adventure

 * Dio Brando (Patrick Seitz): The main antagonist of the JoJo's Bizarre Adventure Parts Phantom Blood & Stardust Crusaders who reveals that The World can affect the Glitch after encountering it himself & joins Pibby's team.
 * Jotaro Kujo (Matthew Mercer): The main protagonist of Stardust Crusaders who was assimilated by the Glitch during his battle with Dio & has Star Platinum sticking out of him all the time.

One Piece

 * Monkey D. Luffy (Colleen Clinkenbeard): The main protagonist of the One Piece franchise who was assimilated due to the Glitch grabbing his hand when he did his Gum-Gum Pistol move & given a body based off his 4th Gear Bound Form.
 * Roronoa Zoro (Christopher Sabat): A member of the Straw Hat Crew who was assimilated due to not being able to cut the Glitch to save Luffy & is fused with Sanji with his swords now serving as wristblades.
 * Vinsmoke Sanji (Eric Vale): The cook of the Straw Hat Crew who was assimilated trying to rescue Nami & is fused with Zoro with the fusion being able to light its feet on fire.
 * Boa Hancock (Lydia Mackay): The Empress of the isolated Amazon Lily & captain of the Kuja Pirates who the Glitch couldn't assimilated without getting its minions petrified after trying to add her & joins Pibby's team to save Luffy.

My Hero Academia

 * Deku (Justin Briner): The main protagonist of My Hero Academia who was assimilated trying to save civilians after losing everyone & is given an appearance based off his Dark Deku costume.
 * Uravity (Luci Christin): 1 of Deku's classmates who was assimilated after lifting Deku & Froppy into the air to buy them time & is fused with Froppy & Creati as she sticks out of Froppy & her right arm remains free, so the Glitch can use her Zero Gravity Quirk to make it easier for it assimilate everyone.
 * Froppy (Monica Rial): Another 1 of Deku's classmates who was assimilated after tossing Deku to safety & is fused with Uravity & Creati with her being the base, spitting out Glitch blobs with her mouth & using her tongue to grab victims.
 * Creati (Colleen Clinkenbeard): The vice president of Deku's class who was assimilated after telling Deku, Uravity & Froppy to run & is fused with the latter 2 with her left arm having her bo staff sticking out of her palm.

RWBY

 * Ruby Rose (Lindsay Jones): The main protagonist of RWBY who was assimilated by the Glitch & the Crescent Rose is fused to her left arm, while her right arm was turned into a scythe made of glitches, while also having her eyes silver like if she's using her silver eyes.
 * Weiss Schnee (Kara Eberle): 1 of the main protagonists of RWBY who was assimilated by the Glitch & the Myrtenaster is fused to her left arm.
 * Blake Belladonna (Arryn Zech): 1 of the main protagonists of RWBY who was assimilated by the Glitch with her now being to create clones out of the Glitch itself.
 * Yang Xiao Long (Barbara Dunkleman): 1 of the main protagonists of RWBY who was assimilated by the Glitch with a glitch arm filling for her right prosthetic arm.
 * Neopolitan (Casey Lee Williams): An antagonist of RWBY who joined Pibby's team due to escaping the Glitch with her illusion with Pibby having Alloy Boy & Melira learn how to use sign language to talk to her.

Miscellaneous

 * Son Goku (Sean Schemmel): The main protagonist of the Dragon Ball franchise who was assimilated by the Glitch due to him not realizing that it can absorb ki & was given a glitch body akin to the Oozaru transformation.
 * Naruto Uzumaki (Maile Flanagan): The main protagonist of the Naruto franchise who was assimilated by the Glitch & was given a glitch body akin to his Nine-Tails Chakra mode.
 * Homura Akemi (Cristina Vee): A main character from Puella Magica Madoka Magica who was assimilated by the Glitch, while trying to save Madoka & was given a glitch body akin to her Witch form.
 * Saitama (Max Mittelman): The main protagonist of One Punch Man who joined Pibby's team since his 1 punch was able to defeat any minion the Glitch threw at him.
 * Sucy Manbavaran (Rachelle Hager): 1 of the main protagonists of Little Witch Academia who was assimilated by the Glitch & has glitch essence in the form of mushrooms growing on her, which can release glitch spores like mushrooms would.
 * Ryūko Matoi (Erica Mendez): The main protagonist of Kill la Kill who was assimilated by the Glitch & was transformed into her Berserk form, but with both Scissor Blades on her arms.
 * Megumin (Erica Mendez): 1 of the main protagonists of KonoSuba: God's Blessing on this Wonderful World! who was assimilated by the Glitch due to collapsing after using Explosion on it.
 * Retsuko (Erica Mendez): The main protagonist of Aggretsuko who was assimilated & given glitch effects on her face to reference the many times she started singing death metal.
 * Komi Shouko: The main protagonist of Komi Can't Communicate who was assimilated by the Glitch due to being unable to warn everyone.

Miscellaneous

 * Homer (Dan Castellaneta): The main protagonist of The Simpsons who was assimilated due to strangling Bart after he got assimilated, which the Glitch to drag him into it.

South Park

 * Stan Marsh (Trey Parker): 1 of the main protagonists of South Park who was assimilated with the Glitch & fused with Kyle, Cartman & Kenny into a glitch body.
 * Kyle Broflovski (Matt Stone): 1 of the main protagonists of South Park who was assimilated with the Glitch & fused with Stan, Cartman & Kenny into a glitch body.
 * Eric Cartman (Trey Parker): 1 of the main protagonists of South Park who was assimilated with the Glitch & fused with Stan, Kyle & Kenny into a glitch body.
 * Kenny McCormick (Matt Stone): 1 of the main protagonists of South Park who was assimilated with the Glitch as well as the first one to & fused with Stan, Kyle & Cartman into a glitch body.

Hazbin Hotel

 * Charlie (Jill Harris):
 * Vaggie (Monica Franco):
 * Angel Dust (Michael Kovach):

Family Guy

 * Stewie Griffin (Seth MacFarlane):
 * Brian Griffin (Seth MacFarlane):

My Little Pony: Friendship is Magic

 * Twilight Sparkle (Tara Strong):
 * Applejack (Ashleigh Ball):
 * Fluttershy (Andrea Libman):
 * Pinkie Pie (Andrea Libman):
 * Rarity (Tabitha St. Germain):